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Regarding prescribing: under the Human Medicines Regulations 2012 (regulation 167), doctors and some independent prescribers may prescribe unlicensed medicines (known as 'specials') when clinically necessary and when no licensed alternative is suitable, taking personal responsibility for that decision (GMC: Good practice in prescribing and managing medicines and devices)

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barbarum berries in China, thus questioning the intended use of these pesticides in such fruits and their associated risks for human health

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For species level estimations (described in 46 ) in the heatmap, most of the OTUs could not be resolved to the species level (100% identity and coverage on NCBIs nucleotide BLAST: using the 16S rRNA database), and are thus reported as the resultant genera from our 16S sequencing